ThesisOpen AccessMetadata saja
2025•Skripsi, Thesis, Disertasi, dan Tugas Akhir
Hypertension or high blood pressure is a disease that can lead to other diseases such as stroke and coronary heart disease. One of the causes of hypertension is fluid retention, which leads to an increase in blood volume. The medication that can reduce excess body fluid is a diuretic. Avocado leaves contain flavonoids that have the potential to act as diuretics, thereby reducing blood volume. The aim of this research is to determine the formula of avocado leaf tea that has the most optimal diuretic effect. This study uses a posttest-only control group design experimental method. The treatment groups were divided into 4: a negative control group (1% Na CMC), a positive control group (Furosemide), avocado leaf tea 4 g, and avocado leaf tea 8 g in 200 ml of water, at a temperature of 100°C for 5 minutes. Observation was conducted by measuring the cumulative urine volume over 6 hours. Data analysis used the one-way ANOVA test if normally distributed and the Kruskal-Wallis test if not normally distributed, using SPSS version 26. The obtained diuretic activity is compared with the diuretic scale. The average urine volume results over 6 hours for groups I, II, III, and IV were 0.178 ml; 0.701 ml; 0.376 ml; and 1.61 ml, respectively. The results of this study indicate that avocado leaf tea infusion has the potential to act as a diuretic in male Swiss white mice. The 12 g avocado leaf tea infusion formula showed the most optimum diuretic effect (p≥ 0.05) with a strong diuretic activity of 1.654.
ThesisOpen AccessMetadata saja
2025•Skripsi, Thesis, Disertasi, dan Tugas Akhir
Hipertensi merupakan suatu peningkatan tekanan darah sistolik ≥140 mmHg dan tekanan darah diastolik ≥90 mmHg. Pisang ambon memiliki kandungan kalium yang tinggi sehingga baik untuk menjaga tekanan darah tetap stabil. Kalium memiliki efek diuretik yang dapat menurunkan tekanan darah dengan meningkatkan pengeluaran natrium dan air melalui urin. Penelitian ini bertujuan untuk mengetahui efek diuretik pisang ambon pada tikus putih jantan galur wistar.
Penelitian ini menggunakan metode eksperimental dengan desain penelitian post test only control group design. Sebanyak 27 ekor tikus putih jantan galur wistar dibagi menjadi tiga kelompok yaitu kelompok kontrol negatif (CMC Na), kelompok kontrol positif (furosemide), dan kelompok perlakuan (pisang ambon). Pengujian efektivitas diuretik dilakukan dengan melihat volume urin dari ketiga kelompok tiap 1 jam selama 6 jam. Hasil volume urin dianalisis menggunakan Kruskal Wallis IBM SPSS Statistics versi 26 dengan taraf kepercayaan 95%.
Hasil rerata volume urin selama 6 jam pada kelompok I, II, dan III secara berturut-turut yaitu 4,308 ml; 37,987 ml; dan 22,059 ml. Kesimpulan pada penelitian ini adalah pisang ambon memiliki efektivitas sebagai diuretik pada tikus putih jantan galur wistar dengan pemberian pisang ambon seberat 17,599 g, namun efektivitas diuretik yang dihasilkan pisang ambon tidak sekuat furosemide yang merupakan loop diuretic.
Hypertension is an increase in systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg. Ambon banana has a high potassium content so that is good for keeping blood pressure stable. Potassium has a diuretic effect that can lower blood pressure by increasing the excretion of sodium and water through urine. This study aims to determine the diuretic effect of ambon banana on male white rats wistar strain.
This study used an experimental method with a post test only control group design. A total of 27 male white rats wistar strain were divided into three groups: negative control group (CMC Na), positive control group (furosemide), and treatment group (ambon banana). Testing the effectiveness of diuretics was carried out by looking at the urine volume of the three groups every 1 hour for 6 hours. Urine volume results were analyzed using Kruskal Wallis IBM SPSS Statistics version 26 with 95% confidence level.
The average urine volume for 6 hours in groups I, II, and III were 4,308 ml; 37,987 ml; and 22,059 ml, respectively. The conclusion of this study is that ambon banana has effectiveness as a diuretic in male white rats wistar strain by giving 17,599 g of ambon banana, but the diuretic effectiveness of ambon banana is not as strong as furosemide which is a loop diuretic.
