ThesisOpen AccessMetadata saja
2026•Skripsi, Thesis, Disertasi, dan Tugas Akhir
Minyak zaitun memiliki aktivitas antioksidan dan sifat emolien yang dapat melembapkan serta melindungi kulit dari radikal bebas. Penggunaannya dapat diformulasikan dalam bentuk sediaan lotion dengan menggunakan basis gliseril monostearat. Penelitian ini bertujuan untuk menganalisis apakah sediaan lotion minyak zaitun memenuhi persyaratan viskositas dan diameter sebar sesuai standar. Penelitian ini menggunakan metode eksperimental dengan rancangan posttest only design. Sediaan dibuat dalam dua formula, yaitu F1 (lotion tanpa minyak zaitun) dan F2 (lotion dengan minyak zaitun). Pengujian diameter sebar dilakukan dengan tiga kali replikasi, sedangkan pengujian viskositas dilakukan dengan tiga kali repetisi pada setiap formula. Data dianalisis menggunakan SPSS 25 melalui uji normalitas dan homogenitas, kemudian dilanjutkan dengan independent sample ttest dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa diameter sebar F1 dan F2 masingmasing sebesar 5,58±0,13 cm dan 5,03±0,03 cm, serta viskositas sebesar 14.039 mPa’s dan 25.050 mPa’s. F1 memenuhi persyaratan viskositas dan diameter sebar, sedangkan F2 tidak memenuhi persyaratan viskositas karena melebihi batas yang ditetapkan. Penambahan minyak zaitun meningkatkan viskositas sehingga menurunkan diameter sebar. Kesimpulan Sediaan lotion minyak zaitun dengan basis gliseril monostearat memenuhi karakteristik fisik pada uji diameter sebar dan uji viskositas.
ThesisOpen AccessMetadata saja
2025•Skripsi, Thesis, Disertasi, dan Tugas Akhir
Hypertension or high blood pressure is a disease that can lead to other diseases such as stroke and coronary heart disease. One of the causes of hypertension is fluid retention, which leads to an increase in blood volume. The medication that can reduce excess body fluid is a diuretic. Avocado leaves contain flavonoids that have the potential to act as diuretics, thereby reducing blood volume. The aim of this research is to determine the formula of avocado leaf tea that has the most optimal diuretic effect. This study uses a posttest-only control group design experimental method. The treatment groups were divided into 4: a negative control group (1% Na CMC), a positive control group (Furosemide), avocado leaf tea 4 g, and avocado leaf tea 8 g in 200 ml of water, at a temperature of 100°C for 5 minutes. Observation was conducted by measuring the cumulative urine volume over 6 hours. Data analysis used the one-way ANOVA test if normally distributed and the Kruskal-Wallis test if not normally distributed, using SPSS version 26. The obtained diuretic activity is compared with the diuretic scale. The average urine volume results over 6 hours for groups I, II, III, and IV were 0.178 ml; 0.701 ml; 0.376 ml; and 1.61 ml, respectively. The results of this study indicate that avocado leaf tea infusion has the potential to act as a diuretic in male Swiss white mice. The 12 g avocado leaf tea infusion formula showed the most optimum diuretic effect (p≥ 0.05) with a strong diuretic activity of 1.654.
ThesisOpen AccessMetadata saja
2025•Skripsi, Thesis, Disertasi, dan Tugas Akhir
Buah naga merah memiliki aktivitas antioksidan yang tergolong kuat. Pemanfaatan buah naga merah untuk kesehatan kulit dapat dioptimalkan dalam bentuk sediaan krim. Penelitian ini bertujuan mengetahui pengaruh penggunaan emulgator terhadap karakteristik fisik pada sediaan krim sari buah naga merah. Penelitian ini menggunakan metode eksperimental posttest only design. Formulasi yang dibuat terdiri dari 3 formulasi krim sari buah naga merah dengan perbedaan konsentrasi asam stearat 5%, 10% dan 15%. Analisis data statistik dengan uji One way ANOVA dan uji Tukey untuk mengetahui perbedaan variasi konsentrasi asam stearat. Hasil uji organoleptis dan homogonetis secara deskriptif dengan hasil F1 warna merah muda, tidak berbau, konsistensi agak kental, F2 dan F3 warna merah muda, tidak berbau, konsistensi kental. Ketiga formula memiliki homogenitas yang homogen. Hasil uji pH F1(7,2 ±0,05), F2 (6,4±0,05) dan F3 (5,9±0,1) memiliki perbedaan bermakna (sig0,05). Hasil diameter sebar F1(6,1±0,1), F2 (5,6±0,07) dan F3 (5,1±0,02) memiliki perbedaan bermakna (sig0,05). Kesimpulan formulasi krim sari buah naga merah memenuhi persyaratan uji organoleptis, uji homogenitas, uji pH dan diameter.
ThesisOpen AccessMetadata saja
2024•Skripsi, Thesis, Disertasi, dan Tugas Akhir
Tea leaf extract contains high antioxidants in the form of catechins that can be utilised in cosmetic preparations. Tea leaf extract is formulated in the form of a cream preparation with varying concentrations of stearic acid to facilitate use. This study aims to determine the physicochemical properties of tea leaf extract cream preparations with varying concentrations of stearic acid. The research method used Post Test Only Design. Extraction of tea leaf powder using 96% ethanol solvent by remaseration method. Tea leaf extract was made into cream preparations with variations in stearic acid concentrations F1 (10%), F2 (12.5%), and F3 (15%). Cream preparations were evaluated for physicochemical properties including organoleptic test, homogeneity test, pH test and spread diameter test. Data from organoleptic and homogeneity tests were analysed descriptively. The pH test and spread diameter were analysed with SPSS 26, using One Way Anova test followed by LSD test. The results of the organoleptic test showed that the cream had a yellowish green colour, a distinctive smell of tea leaves, and the form of F1 was slightly thick, F2 was thick, and F3 was very thick. Homogeneity test showed all three formulas were homogeneous. The pH test results showed F1 (7.89±0.13), F2 (7.65±0.10), and F3 (7.32±0.23). Spread diameter test showed F1 (6.49±0.03cm), F2 (5.33±0.16cm), and F3 (4.84±0.07cm). Organoleptic, homogenised, and pH tests met the requirements while the spread diameter test did not meet the requirements.
ThesisOpen AccessMetadata saja
2024•Skripsi, Thesis, Disertasi, dan Tugas Akhir
Green tea leaves contain alkaloid compounds, tannins, saponins, steroids or triterpenoids, flavonoids and polyphenols that can be used as antioxidants. The use of green tea leaves as an antioxidant can be facilitated by being made into lotion preparations. The purpose of this study was to determine the lotion of green tea leaf extract with varying concentrations of glyceryl monostearate meets the physicochemical requirements based on organoleptical testing, homogeneity, pH and diameter spread. The research method used Posttest Only Group Design. Extraction of green tea leaf powder using maceration method using 96% solvent. Green tea leaf extract was made into lotion preparations using glyceryl monostearate base with various concentrations of F1 (7.5%), F2 (10%) and F3 (12.5%). Organoleptic and homogeneity tests were analyzed descriptively while pH and spread diameter were analyzed using SPSS 25. Normality test used Shapiro-Wilk test and homogeneity test used Levene's test. If the data is normally distributed and homogeneous (Sig>0.05) then proceed with the One Way Anova test. If in the One Way Anova test there is a significant difference (Sig 0.05) then proceed with the LSD test. If the data is not normally distributed, the Kruskall Wallis test is performed. If in the Kruskall Wallis test there is a significant difference (Sig 0.05) then proceed to use the Mann Whitney test.
