Abstrak
Diabetes mellitus is a chronic disease caused by the pancreas not being able to produce enough insulin or not being able to use the insulin produced effectively. The prevalence of diabetes mellitus in Indonesia reaches 8.5%, of which about 90% are cases of type 2 diabetes mellitus. This study aims to determine the effect of different oral antidiabetic therapies on the HbA1c levels of patients with type II diabetes mellitus at the Puskesmas Pleret. The research method used is observational analytical with retrospective data collection on the medical records of patients with type 2 diabetes mellitus. The population in this study consists of all medical records of prolanis patients diagnosed with type 2 diabetes mellitus at Puskesmas Pleret in May 2025. Sampling was conducted using a saturated sampling technique. Data analysis includes patient characteristics, the use of oral antidiabetic agents, achievement of HbA1c, and the effect of oral antidiabetic agents on HbA1c using Chi-Square in SPSS version 25 to determine the impact of the type of antidiabetic medication on HbA1c levels. The results and conclusions of this study show that the majority of patients are female (80%) with the most common age range being 55-65 years (52.3%). The type of therapy most commonly used is combination therapy (64.4%), with HbA1c not achieved in those receiving combination therapy of biguanides and sulfonylureas (40%). The data analyzed using Chi-Square test showed no effect of the type of oral antidiabetic therapy on HbA1c levels (p= 0.691).